2020-11-05 09:07:27 CBAY Acquired by GILD
11/05/20 11/0509:07 11/05/2009:07 | CymaBay announces study to evaluate potential of GPR119 agonistsCymaBay Therapeutics announced it will provide its proprietary investigational GPR119 agonist, MBX-2982, and will assist in regulatory filings for a clinical study to be conducted by the TRI. CymaBay wholly owns and retains all rights to MBX-2982. The objective of the study is to determine if GPR119 agonists have potential to prevent hypoglycemia for people living with T1D. The trial is funded by a nearly $1.2 million grant from The Leona M. and Harry B. Helmsley Charitable Trust. Glucagon is a hormone secreted by the pancreas, that naturally reverses hypoglycemia by signaling the body to release stored glucose. This process is defective in individuals with insulin-dependent diabetes, such as T1D. If left uncorrected, hypoglycemia can lead to unconsciousness or death. Preventing episodes of hypoglycemia in persons with diabetes is an unmet medical need: according to the 2016 global HAT study of 27,000 people, 4 out of 5 individuals with T1D reported hypoglycemia, with a rate of severe hypoglycemia of approximately 5 events per patient-year. In recent preclinical studies, GPR119 agonists were shown to enhance glucagon secretion in response to low glucose levels, and were able to prevent hypoglycemia in animal models. To translate these findings, the TRI in Orlando, FL will test CymaBay's MBX-2982 in a Phase 2a proof-of-pharmacology study to determine whether the drug can enhance glucagon secretion during insulin-induced hypoglycemia in subjects with T1D. |
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