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RVNC

Revance

$27.50 /

+0.99 (+3.73%)

16:15
11/09/20
11/09
16:15
11/09/20
16:15

Revance's phase 2 trial for Daxibotulin does not meet primary efficacy endpoint

Revance Therapeutics announced results from its Phase 2 clinical trial of investigational drug candidate DaxibotulinumtoxinA for Injection for the management of plantar fasciitis. This Phase 2 prospective, randomized, double-blind, multi-center, placebo-controlled trial evaluated the safety and efficacy of two doses of DaxibotulinumtoxinA for Injection in reducing the signs and symptoms of plantar fasciitis. The trial enrolled 155 adult patients with unilateral plantar fasciitis, 18 to 65 years of age, at 17 study centers in the United States. Patients were randomized (1:1:1) to receive an injection of DAXI 80 U, DAXI 120 U or placebo. The study's primary efficacy endpoint was the change from baseline on the 10-point Numeric Pain Rating Scale score averaged over five days at Week 8. Patients were followed for up to 24 weeks post treatment to assess treatment response, tolerability and safety. In the trial, both doses of DaxibotulinumtoxinA for Injection resulted in significant, measurable pain relief after treatment that was numerically greater than placebo. However, neither dose met the primary efficacy endpoint of statistically significant improvement from baseline in the NPRS for foot pain at Week 8, compared to placebo. Subjects treated with DaxibotulinumtoxinA for Injection showed an average reduction from baseline of 3.29 on the NPRS (a 54.6% reduction) at 80U (p=0.2135 vs. placebo) and 3.25 on the NPRS (a 50.1% reduction) at 120U (p=0.2205 vs. placebo, p=0.9207 vs. 80U), compared to placebo subjects at 2.75 on the NPRS (a 45.1% reduction).

  • 09

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    Nov

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    Dec

RVNC Revance
$27.50 /

+0.99 (+3.73%)

10/26/20 Barclays
Revance price target raised to $38 from $35 at Barclays
10/15/20 H.C. Wainwright
Revance price target raised to $33 from $27 at H.C. Wainwright
09/28/20 Barclays
Revance price target raised to $35 from $32 at Barclays
08/11/20 Mizuho
Revance assumed with a Buy at Mizuho

TODAY'S FREE FLY STORIES

Recommendations
Stantec price target raised to C$46 from C$43 at Scotiabank » 11:26
12/04/20
12/04
11:26
12/04/20
11:26
STN

Stantec

$31.63 /

+0.96 (+3.13%)

Scotiabank analyst Mark…

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STN Stantec
$31.63 /

+0.96 (+3.13%)

STN Stantec
$31.63 /

+0.96 (+3.13%)

11/06/20 CIBC
Stantec price target lowered to C$45 from C$49 at CIBC
11/06/20 Canaccord
Stantec price target lowered to C$49 from C$51 at Canaccord
11/06/20 RBC Capital
Stantec price target lowered to C$45 from C$47 at RBC Capital
11/06/20 BMO Capital
Stantec price target lowered to C$41 from C$42 at BMO Capital
STN Stantec
$31.63 /

+0.96 (+3.13%)

Recommendations
Precision BioSciences data provide clear path forward, says BTIG » 11:25
12/04/20
12/04
11:25
12/04/20
11:25
DTIL

Precision BioSciences

$8.09 /

-2.15 (-21.00%)

BTIG analyst Thomas…

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DTIL Precision BioSciences
$8.09 /

-2.15 (-21.00%)

DTIL Precision BioSciences
$8.09 /

-2.15 (-21.00%)

11/20/20 Stifel
Precision BioSciences price target raised to $22 from $21 at Stifel
10/21/20 Stifel
Crispr Therapeutics price target raised to $93 from $75 at Stifel
07/27/20 BTIG
Precision BioSciences assumed with a Buy at BTIG
05/18/20 H.C. Wainwright
Precision BioSciences could have 'significant upside,' says H.C. Wainwright
DTIL Precision BioSciences
$8.09 /

-2.15 (-21.00%)

DTIL Precision BioSciences
$8.09 /

-2.15 (-21.00%)

Syndicate
Sigilon Therapeutics indicated to open at $22.40, IPO priced at $18.00  11:25
12/04/20
12/04
11:25
12/04/20
11:25
SGTX

Sigilon Therapeutics

$0.00 /

+ (+0.00%)

 
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  • 04
    Dec
Options
Taiwan Semi call volume above normal and directionally bullish » 11:25
12/04/20
12/04
11:25
12/04/20
11:25
TSM

TSMC

$102.77 /

+3.31 (+3.33%)

Bullish option flow…

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TSM TSMC
$102.77 /

+3.31 (+3.33%)

TSM TSMC
$102.77 /

+3.31 (+3.33%)

10/29/20 Craig-Hallum
FormFactor price target raised to $35 from $30 at Craig-Hallum
10/23/20 Jefferies
TSMC clearly has 'stronger hand' if Intel comes to negotiate, says Jefferies
08/28/20 New Street
TSMC initiated with a Buy at New Street
08/24/20 Northland
Northland downgrades AMD to Market Perform on potential Intel, data center risks
TSM TSMC
$102.77 /

+3.31 (+3.33%)

TSM TSMC
$102.77 /

+3.31 (+3.33%)

TSM TSMC
$102.77 /

+3.31 (+3.33%)

TSM TSMC
$102.77 /

+3.31 (+3.33%)

Conference/Events
Sempra Energy to host business news update conference call » 11:25
12/04/20
12/04
11:25
12/04/20
11:25
SRE

Sempra Energy

$129.63 /

-2.34 (-1.77%)

Management holds an…

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SRE Sempra Energy
$129.63 /

-2.34 (-1.77%)

SRE Sempra Energy
$129.63 /

-2.34 (-1.77%)

11/18/20 Barclays
Sempra Energy price target raised to $159 from $146 at Barclays
09/11/20 Mizuho
Sempra Energy price target lowered to $119 from $137 at Mizuho
08/17/20
Fly Intel: Top five analyst downgrades
08/17/20 Wells Fargo
Sempra Energy downgraded to Equal Weight on valuation at Wells Fargo
SRE Sempra Energy
$129.63 /

-2.34 (-1.77%)

Syndicate
Seer indicated to open at $40.05, IPO priced at $19.00  11:25
12/04/20
12/04
11:25
12/04/20
11:25
SEER

Seer

$0.00 /

+ (+0.00%)

 
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  • 04
    Dec
Recommendations
Intact Financial price target raised to C$175 from C$166 at Scotiabank » 11:24
12/04/20
12/04
11:24
12/04/20
11:24
IFCZF

Intact Financial

$0.00 /

+ (+0.00%)

Scotiabank analyst Phil…

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IFCZF Intact Financial
$0.00 /

+ (+0.00%)

11:09 Today TD Securities
Intact Financial resumed with a Buy at TD Securities
11/06/20 CIBC
Intact Financial upgraded to Outperformer from Neutral at CIBC
11/05/20 CIBC
Intact Financial price target raised to C$160 from C$155 at CIBC
11/05/20 Scotiabank
Intact Financial price target raised to C$166 from C$161 at Scotiabank
Recommendations
Goodfood Market price target lowered to C$11 from C$11.50 at Scotiabank » 11:24
12/04/20
12/04
11:24
12/04/20
11:24
GDDFF

Goodfood Market

$0.00 /

+ (+0.00%)

Scotiabank analyst George…

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GDDFF Goodfood Market
$0.00 /

+ (+0.00%)

GDDFF Goodfood Market
$0.00 /

+ (+0.00%)

11/12/20 Raymond James
Goodfood Market price target raised to C$12.50 from C$9.15 at Raymond James
11/12/20 Stifel
Goodfood Market price target raised to C$14 from C$12 at Stifel
11/12/20 National Bank
Goodfood Market price target raised to C$11 from C$10.50 at National Bank
11/09/20 Stifel
Goodfood Market price target raised to C$12 from C$10 at Stifel
Recommendations
Capital Power price target raised to C$37 from C$35 at Scotiabank » 11:22
12/04/20
12/04
11:22
12/04/20
11:22
CPXWF

Capital Power

$0.00 /

+ (+0.00%)

Scotiabank analyst Robert…

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CPXWF Capital Power
$0.00 /

+ (+0.00%)

CPXWF Capital Power
$0.00 /

+ (+0.00%)

10:57 Today TD Securities
Capital Power price target raised to C$39 from C$37 at TD Securities
11/03/20 BMO Capital
Capital Power price target raised to C$29 from C$28 at BMO Capital
10/15/20 CIBC
Capital Power price target raised to C$34 from C$33 at CIBC
08/05/20 RBC Capital
Capital Power price target raised to C$31 from C$30 at RBC Capital
CPXWF Capital Power
$0.00 /

+ (+0.00%)

Technical Analysis
NASDAQ market internals summary » 11:17
12/04/20
12/04
11:17
12/04/20
11:17
$NSD

NASDAQ Market Internals

$0.00 /

+ (+0.00%)

Volume is above average…

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$NSD NASDAQ Market Internals
$0.00 /

+ (+0.00%)

Hot Stocks
KLM, Delta to offer COVID-19 tested flights from Atlanta to Amsterdam » 11:17
12/04/20
12/04
11:17
12/04/20
11:17
DAL

Delta Air Lines

$42.39 /

-0.58 (-1.35%)

, AFLYY

Air France-KLM

$0.00 /

+ (+0.00%)

Delta Air Lines (DAL) and…

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DAL Delta Air Lines
$42.39 /

-0.58 (-1.35%)

DAL Delta Air Lines
$42.39 /

-0.58 (-1.35%)

07:27 Today Wolfe Research
Wolfe cuts Delta, United and Boeing to Underperform, sees too much optimism
06:07 Today Wolfe Research
Delta Air Lines downgraded to Underperform from Peer Perform at Wolfe Research
11/30/20
Fly Intel: Top five analyst downgrades
11/30/20 Raymond James
Delta Air Lines downgraded to Market Perform from Outperform at Raymond James
AFLYY Air France-KLM
$0.00 /

+ (+0.00%)

12/01/20 UBS
Air France-KLM price target raised to EUR 4.45 from EUR 3.35 at UBS
11/12/20 Kepler Cheuvreux
Air France-KLM upgraded to Hold from Reduce at Kepler Cheuvreux
11/10/20 Goldman Sachs
Air France-KLM initiated with a Sell at Goldman Sachs
10/23/20 ABN Amro
Air France-KLM downgraded to Sell from Hold at ABN Amro
DAL Delta Air Lines
$42.39 /

-0.58 (-1.35%)

AFLYY Air France-KLM
$0.00 /

+ (+0.00%)

DAL Delta Air Lines
$42.39 /

-0.58 (-1.35%)

AFLYY Air France-KLM
$0.00 /

+ (+0.00%)

DAL Delta Air Lines
$42.39 /

-0.58 (-1.35%)

DAL Delta Air Lines
$42.39 /

-0.58 (-1.35%)

Technical Analysis
NYSE market internals summary » 11:16
12/04/20
12/04
11:16
12/04/20
11:16
$NYE

NYSE Market Internals

$0.00 /

+ (+0.00%)

Volume is above average…

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$NYE NYSE Market Internals
$0.00 /

+ (+0.00%)

Options
International Flavors put volume heavy and directionally bearish » 11:15
12/04/20
12/04
11:15
12/04/20
11:15
IFF

IFF

$114.92 /

+2.28 (+2.02%)

Bearish flow noted in…

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IFF IFF
$114.92 /

+2.28 (+2.02%)

IFF IFF
$114.92 /

+2.28 (+2.02%)

11/12/20 Societe Generale
IFF upgraded to Hold from Sell at Societe Generale
10/09/20 BofA
IFF initiated with a Buy at BofA
08/26/20 Baird
IFF initiated with an Outperform at Baird
07/09/20
IFF initiated with an Overweight at Stephens
IFF IFF
$114.92 /

+2.28 (+2.02%)

IFF IFF
$114.92 /

+2.28 (+2.02%)

Syndicate
Sigilon Therapeutics indicated to open at $22, IPO priced at $18  11:11
12/04/20
12/04
11:11
12/04/20
11:11
SGTX

Sigilon Therapeutics

$0.00 /

+ (+0.00%)

 
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  • 04
    Dec
Initiation
Intact Financial resumed with a Buy at TD Securities » 11:09
12/04/20
12/04
11:09
12/04/20
11:09
IFCZF

Intact Financial

$0.00 /

+ (+0.00%)

TD Securities analyst…

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IFCZF Intact Financial
$0.00 /

+ (+0.00%)

11/06/20 CIBC
Intact Financial upgraded to Outperformer from Neutral at CIBC
11/05/20 CIBC
Intact Financial price target raised to C$160 from C$155 at CIBC
11/05/20 Scotiabank
Intact Financial price target raised to C$166 from C$161 at Scotiabank
11/04/20 RBC Capital
Intact Financial price target raised to C$163 from C$160 at RBC Capital
Syndicate
Silverback Therapeutics indicated to open at $29.50, IPO priced at $21.00 » 11:07
12/04/20
12/04
11:07
12/04/20
11:07
SBTX

Silverback Therapeutics

$0.00 /

+ (+0.00%)

Silverback Therapeutics…

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  • 04
    Dec
Syndicate
Sigilon Therapeutics indicated to open at $20.50, IPO priced at $18.00  11:05
12/04/20
12/04
11:05
12/04/20
11:05
SGTX

Sigilon Therapeutics

$0.00 /

+ (+0.00%)

 
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  • 04
    Dec
Syndicate
17 Entertainment opens at $10.50, IPO priced at $10.50 per share  11:00
12/04/20
12/04
11:00
12/04/20
11:00
YQ

17 Entertainment

$0.00 /

+ (+0.00%)

 
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  • 04
    Dec
Options
Unusual call volume in Purple Innovation as shares traded up 4% » 11:00
12/04/20
12/04
11:00
12/04/20
11:00
PRPL

Purple Innovation

$31.16 /

+2.01 (+6.90%)

Unusual call volume in…

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PRPL Purple Innovation
$31.16 /

+2.01 (+6.90%)

PRPL Purple Innovation
$31.16 /

+2.01 (+6.90%)

11/12/20 Roth Capital
Purple Innovation price target raised to $32 from $27 at Roth Capital
11/10/20 KeyBanc
Purple Innovation price target raised to $34 from $26 at KeyBanc
10/26/20 Raymond James
Purple Innovation price target raised to $36 from $28 at Raymond James
10/20/20 Craig-Hallum
Purple Innovation price target raised to $40 from $32 at Craig-Hallum
PRPL Purple Innovation
$31.16 /

+2.01 (+6.90%)

  • 10
    Sep
  • 15
    May
PRPL Purple Innovation
$31.16 /

+2.01 (+6.90%)

PRPL Purple Innovation
$31.16 /

+2.01 (+6.90%)

Recommendations
Baytex Energy price target raised to C$0.75 from C$0.55 at TD Securities » 10:58
12/04/20
12/04
10:58
12/04/20
10:58
BTE

Baytex Energy

$0.52 /

+ (+0.00%)

TD Securities analyst…

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BTE Baytex Energy
$0.52 /

+ (+0.00%)

BTE Baytex Energy
$0.52 /

+ (+0.00%)

12/03/20 Raymond James
Baytex Energy price target raised to C$0.70 from C$0.50 at Raymond James
12/03/20 BMO Capital
Baytex Energy price target raised to C$0.75 from C$0.60 at BMO Capital
12/03/20 Canaccord
Baytex Energy price target raised to C$0.75 from C$0.60 at Canaccord
10/16/20 National Bank
Baytex Energy price target lowered to C$0.75 from C$0.90 at National Bank
BTE Baytex Energy
$0.52 /

+ (+0.00%)

Recommendations
WSP Global price target raised to C$130 from C$105 at TD Securities » 10:57
12/04/20
12/04
10:57
12/04/20
10:57
WSPOF

WSP Global

$0.00 /

+ (+0.00%)

TD Securities analyst…

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WSPOF WSP Global
$0.00 /

+ (+0.00%)

WSPOF WSP Global
$0.00 /

+ (+0.00%)

11/06/20 CIBC
WSP Global price target raised to C$103 from C$102 at CIBC
11/06/20 RBC Capital
WSP Global price target raised to C$104 from C$101 at RBC Capital
11/06/20 BMO Capital
WSP Global price target raised to C$91 from C$87 at BMO Capital
08/07/20 BMO Capital
WSP Global price target lowered to C$87 from C$89 at BMO Capital
Recommendations
Capital Power price target raised to C$39 from C$37 at TD Securities » 10:57
12/04/20
12/04
10:57
12/04/20
10:57
CPXWF

Capital Power

$0.00 /

+ (+0.00%)

TD Securities analyst…

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CPXWF Capital Power
$0.00 /

+ (+0.00%)

CPXWF Capital Power
$0.00 /

+ (+0.00%)

11/03/20 BMO Capital
Capital Power price target raised to C$29 from C$28 at BMO Capital
10/15/20 CIBC
Capital Power price target raised to C$34 from C$33 at CIBC
08/05/20 RBC Capital
Capital Power price target raised to C$31 from C$30 at RBC Capital
08/05/20 BMO Capital
Capital Power price target raised to C$27 from C$26 at BMO Capital
CPXWF Capital Power
$0.00 /

+ (+0.00%)

Syndicate
Sigilon Therapeutics indicated to open at $18.10, IPO priced at $18.00 » 10:55
12/04/20
12/04
10:55
12/04/20
10:55
SGTX

Sigilon Therapeutics

$0.00 /

+ (+0.00%)

Sigilon Therapeutics…

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  • 04
    Dec
Syndicate
Seer indicated to open at $36, IPO priced at $19  10:55
12/04/20
12/04
10:55
12/04/20
10:55
SEER

Seer

$0.00 /

+ (+0.00%)

 
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  • 04
    Dec
Options
Lennar put volume heavy and directionally bearish » 10:55
12/04/20
12/04
10:55
12/04/20
10:55
LEN

Lennar

$74.90 /

-0.5 (-0.66%)

Bearish flow noted in…

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LEN Lennar
$74.90 /

-0.5 (-0.66%)

LEN Lennar
$74.90 /

-0.5 (-0.66%)

11/02/20 Atlantic Equities
Lennar initiated with an Overweight at Atlantic Equities
10/26/20 Zelman
Lennar downgraded to Hold from Buy at Zelman
10/13/20 Zelman
TRI Pointe added to Top Idea Basket at Zelman
10/08/20 JPMorgan
Lennar price target raised to $94 from $87 at JPMorgan
LEN Lennar
$74.90 /

-0.5 (-0.66%)

LEN Lennar
$74.90 /

-0.5 (-0.66%)

LEN Lennar
$74.90 /

-0.5 (-0.66%)

LEN Lennar
$74.90 /

-0.5 (-0.66%)

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