2020-12-07 06:15:53 MESO Mesoblast
12/07/20 12/0706:15 12/07/2006:15 | Mesoblast presents results on study of remestemcel-L at ASHMesoblast announced results presented at the 62nd annual meeting American Society of Hematology, which provide in vivo biomarker evidence linking remestemcel-L's immunomodulatory activity to survival outcomes in children with steroid-refractory acute graft versus host disease. The results were presented on December 6, 2020 by the Phase 3 trial's lead investigator and pediatric transplant physician, Dr Joanne Kurtzberg, the Jerome Harris Distinguished Professor of Pediatrics and Professor of Pathology, and Director, Pediatric Blood and Marrow Transplant Program at Duke University Medical Center. Key conclusions were: Clinically meaningful overall responses and survival in children with SR-aGVHD treated with remestemcel-L were associated with significant reductions in certain biomarkers of inflammation which have been validated as predictors of mortality risk. These biomarkers provide evidence of in vivo bioactivity of remestemcel-L in pediatric SR-aGVHD, where children under 12 are at high-risk for mortality, with no approved therapies in the United States. The durable reductions in blood levels of certain biomarkers associated with inflammatory diseases of the gut suggest that these could be more generally reflective of remestemcel-L activity in vivo in other inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. |
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