2020-12-07 08:11:03 XNCR Xencor
12/07/20 12/0708:11 12/07/2008:11 | Xencor in pact with Janssen to discover antibodies to treat prostate cancerXencor (XNCR) announced it has entered into a research collaboration and license agreement with Janssen Biotech (PFE) The research and license agreement is focused on the discovery of XmAb bispecific antibodies against CD28, an immune co-stimulatory receptor on T cells, and an undisclosed prostate tumor target, for the potential treatment of patients with prostate cancer. Additionally, Xencor has a right to access select, predefined agents from Janssen's portfolio of clinical-stage drug candidates and commercialized medicines to evaluate potential combination therapies in prostate cancer with agents in its own pipeline in non-registrational clinical studies. Janssen has the same right with Xencor's portfolio of clinical-stage drug candidates to evaluate potential combination therapies in prostate cancer, as well. "Our XmAb bispecific Fc domains enable the creation of a wide range of multi-specific antibody and protein structures, such as bispecific antibodies in our new CD28 platform. These antibodies can co-stimulate T cells in a tumor-target dependent manner and can synergize with both checkpoint inhibitor therapies and other tumor-targeted agents, like CD3 bispecific antibodies, in order to enhance anti-tumor activity," said Bassil Dahiyat, Ph.D., president and chief executive officer at Xencor. "In addition, the ability to study combinations of therapies from both companies' prostate cancer portfolios leverages Xencor's broad clinical pipeline and the leading prostate cancer therapeutics portfolio at Janssen. This collaboration with Janssen expands the use of our CD28 platform and complements our first wholly owned internal candidate, a B7-H3 x CD28 bispecific antibody designed to treat a range of solid tumors, which is currently advancing through preclinical development." Under the terms of the agreement, Xencor will apply its XmAb bispecific Fc technology to create and characterize XmAb CD28 bispecific antibody candidates against the tumor target specified by Janssen. Preclinical activities and all clinical development, regulatory and commercial activities will be conducted by Janssen, which has exclusive worldwide rights to develop and commercialize the novel drug candidates. Xencor will receive an upfront payment of $50 million and will be eligible to receive development, regulatory and sales milestone payments and high-single digit to low-double digit percent royalties on net sales. Upon clinical proof of concept for a bispecific antibody candidate, Xencor has the right to opt-in to fund 20 percent of development costs and to perform up to 30 percent of the detailing efforts in the United States; Xencor would be eligible for milestone payments and low-double digit to mid-teen percent royalties on net sales. The agreement is subject to customary closing conditions, including clearance under the Hart-Scott-Rodino Antitrust Improvements Act, and closing is expected to occur by year end. |
---|
Hot Stocks
|
GeneDx partners with Komodo Health for rare disease dataset access »
08:34
04/23/24
04/23
08:34
04/23/2408:34
WGS
GeneDx
GeneDx announced a… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
GATX reports Q1 EPS $2.03, consensus $1.76 »
08:33
04/23/24
04/23
08:33
04/23/2408:33
GATX
GATX
Reports Q1 revenue… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Cleveland-Cliffs announces new $1.5B share repurchase program »
08:33
04/23/24
04/23
08:33
04/23/2408:33
CLF
Cleveland-Cliffs
During its earnings… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
PaxMedica responds to emergency request for IV suramin »
08:32
04/23/24
04/23
08:32
04/23/2408:32
PXMD
PaxMedica
PaxMedica expects to take… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Palisade Bio enters strategic collaboration with Strand Life Sciences »
08:32
04/23/24
04/23
08:32
04/23/2408:32
PALI
Palisade Bio
Palisade Bio announced it… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Options
|
One new option listing and thirteen option delistings on April 23rd »
08:31
04/23/24
04/23
08:31
04/23/2408:31
PGTI
PGT Innovations
NGM Biopharmaceuticals
Karuna Therapeutics
Kinnate Biopharma
Daseke
Tritium
Acquired by GILD
Alteryx
Societal CDMO
Bought by CSCO
Textainer
New option listings for… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
Bowlero price target lowered by $2 at Stifel, here's why »
08:29
04/23/24
04/23
08:29
04/23/2408:29
BOWL
Bowlero
Stifel lowered the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
Alignment Healthcare price target lowered by $2 at Stifel, here's why »
08:27
04/23/24
04/23
08:27
04/23/2408:27
ALHC
Alignment Healthcare
Stifel lowered the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
Generac price target raised by $15 at Roth MKM, here's why »
08:27
04/23/24
04/23
08:27
04/23/2408:27
GNRC
Generac
Roth MKM analyst Chip… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
AZZ Inc. price target raised by $18 at B. Riley, here's why »
08:25
04/23/24
04/23
08:25
04/23/2408:25
AZZ
AZZ Inc.
B. Riley raised the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
GE Aerospace says 'never more confident' in path ahead »
08:25
04/23/24
04/23
08:25
04/23/2408:25
GE
GE Aerospace
Says "very… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Conference/Events
|
Heron Therapeutics management to meet virtually with Northland »
08:25
04/23/24
04/23
08:25
04/23/2408:25
HRTX
Heron Therapeutics
Virtual Meeting to be… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Technical Analysis
|
DJ Transportation Average: Pivot points »
08:24
04/23/24
04/23
08:24
04/23/2408:24
$DJT
DJ Transportation Average
The following are the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Technical Analysis
|
DJ Utility Average: Pivot points »
08:24
04/23/24
04/23
08:24
04/23/2408:24
$DJU
DJ Utility Average
The following are the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Technical Analysis
|
Dow Jones Industrial Average: Pivot points »
08:23
04/23/24
04/23
08:23
04/23/2408:23
DJX
Dow Jones Industrial Average
The following are the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Former executive at authID tells White Diamond 'selfie id has no market fit' »
08:23
04/23/24
04/23
08:23
04/23/2408:23
AUID
authID
White Diamond Research… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
374Water, Inc. appoints Chris Gannon as president, CEO »
08:23
04/23/24
04/23
08:23
04/23/2408:23
SCWO
374Water, Inc.
Energy Recovery
374Water (SCWO) announced… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Optimi Health, KPU-AGC partner to advance mushroom science, research »
08:23
04/23/24
04/23
08:23
04/23/2408:23
OPTHF
Optimi Health
Optimi Health announces… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Technical Analysis
|
iShares Transportation Average: Pivot points »
08:23
04/23/24
04/23
08:23
04/23/2408:23
IYT
iShares Transportation Average
The following are the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Downgrade
|
Trilogy Metals just downgraded at Raymond James, here's why »
08:23
04/23/24
04/23
08:23
04/23/2408:23
TMQ
Trilogy Metals
Raymond James downgraded… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Technical Analysis
|
Technology Select Sector SPDR: Pivot points »
08:23
04/23/24
04/23
08:23
04/23/2408:23
XLK
Technology Select Sector SPDR
The following are the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Technical Analysis
|
Energy Select Sector SPDR: Pivot points »
08:23
04/23/24
04/23
08:23
04/23/2408:23
XLE
Energy Select Sector SPDR
The following are the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Alto Neuroscience announces Phase 1 results for ALTO-101 to treat CIAS »
08:23
04/23/24
04/23
08:23
04/23/2408:23
ANRO
Alto Neuroscience
Alto Neuroscience… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Technical Analysis
|
Consumer Discretionary Sector SPDR: Pivot points »
08:22
04/23/24
04/23
08:22
04/23/2408:22
XLY
Consumer Discretionary Sector SPDR
The following are the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Technical Analysis
|
S&P Select Materials SPDR: Pivot points »
08:22
04/23/24
04/23
08:22
04/23/2408:22
XLB
S&P Select Materials SPDR
The following are the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |