2020-12-01 06:43:34 LXRP Use LEXX
12/01/20 12/0106:43 12/01/2006:43 | Lexaria Bioscience says DehydraTECH improved delivery in study animalsLexaria Bioscience announced that its DehydraTECH technology significantly improved delivery in study animals of representative drugs from two classes of antiviral therapies under investigation against SARS-CoV-2/COVID-19 and already in use against HIV/AIDS. These are the first two of a series of antiviral drugs to be tested using Lexaria's DehydraTECH technology. All animals demonstrated excellent safety and tolerability upon dosing with the DehydraTECH formulations, displaying normal activity and behavior throughout the study with no adverse effects. Lexaria plans to conduct expanded investigations into antiviral drug delivery enhancement and effectiveness beginning in January 2021. These plans include additional antiviral drugs that have already demonstrated usefulness in the fight against HIV/AIDS and are being investigated for use against COVID-19. This pilot study included DehydraTECH-formulated drugs administered via oral gavage to male Sprague-Dawley rats compared to concentration-matched controls of the same drugs without DehydraTECH formulation. The study was conducted in a total of 40 rats, broken down into four groups of 10 rats per test article. The drugs evaluated were a protease inhibitor, and a non-nucleoside reverse transcriptase inhibitor; each administered to the rats in a single dose of 10 mg/Kg in either the DehydraTECH formulation or the control formulation under fed study conditions. The study evaluated total drug delivery into the rodent bloodstream, whereby the rats were evaluated over a period of 24 hours post dosing to derive the measured AUC over the period, as well as the extrapolated theoretical maximum AUC expected to be achieved thereafter. The study's positive outcomes may have relevance both for the original antiviral therapeutic indications of the drugs that were studied as well as for additional antiviral drugs within their classes for indications including COVID-19. Drugs like darunavir and efavirenz are mainly used for treatment of HIV/AIDS, although their bioavailability alone in oral form is low at 37% and 45%, respectively. If confirmed through additional expanded testing, DehydraTECH could, in theory, improve this bioavailability rate to as high as 64% which could greatly enhance outcomes thus warranting continued investigation. Furthermore, other types of reverse transcriptase inhibitors like the nucleotide variant remdesivir have already been approved in some jurisdictions for treatment of patients with COVID-19, albeit presently limited to injectable administration due to poor oral bioavailability. Researchers worldwide are also actively evaluating various protease inhibitors that specifically target the main protease associated with SARS-CoV-2 infection in pursuit of additional COVID-19 therapeutic options. If DehydraTECH demonstrates effectiveness in enhancing oral deliverability for compounds in these subclassifications of protease and reverse transcriptase inhibitors, it may hold promise for COVID-19 applicability as well, also warranting further investigation. |
---|
Hot Stocks
|
Ansys announces collaboration with TSMC »
16:31
04/24/24
04/24
16:31
04/24/2416:31
ANSS
Ansys
TSMC
Ansys (ANSS) announced a… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Alerus Financial reports Q1 EPS 32c, consensus 32c »
16:31
04/24/24
04/24
16:31
04/24/2416:31
ALRS
Alerus Financial
President and Chief… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Options
| Preliminary option volume… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
ServiceNow sees Q2 subscription revenues $2.525B-$2.530B, consensus $2.45B »
16:31
04/24/24
04/24
16:31
04/24/2416:31
NOW
ServiceNow
Sees Q2 cRPO growth 20.5%… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Northrim BanCorp reports Q1 EPS $1.48 vs. 84c last year »
16:30
04/24/24
04/24
16:30
04/24/2416:30
NRIM
Northrim BanCorp
Northrim's total… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
PennyMac Mortgage reports Q1 EPS 39c, consensus 32c »
16:29
04/24/24
04/24
16:29
04/24/2416:29
PMT
PennyMac Mortgage
"PMT's results… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
First Bancorp reports Q1 EPS 61c, consensus 63c »
16:28
04/24/24
04/24
16:28
04/24/2416:28
FBNC
First Bancorp
Reports Q1 provision for… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Mid Penn Bancorp reports Q1 EPS 73c, consensus 61c »
16:28
04/24/24
04/24
16:28
04/24/2416:28
MPB
Mid Penn Bancorp
"With the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Conference/Events
|
Capgemini participates in a conference call with Jefferies »
16:28
04/24/24
04/24
16:28
04/24/2416:28
CGEMY
Capgemini
Technology Analyst… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Nabors Industries reports Q1 EPS (4.54), consensus ($1.66) »
16:28
04/24/24
04/24
16:28
04/24/2416:28
NBR
Nabors Industries
Reports Q1 revenue $734M,… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Impinj sees Q2 adjusted EPS 72c-77c, consensus 19c »
16:27
04/24/24
04/24
16:27
04/24/2416:27
PI
Impinj
Sees Q2 revenue… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Univest reports Q1 EPS 69c vs. 71c last year »
16:27
04/24/24
04/24
16:27
04/24/2416:27
UVSP
Univest
Net interest income of… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Molina Healthcare reports Q1 Medical Care Ratio 88.5% »
16:26
04/24/24
04/24
16:26
04/24/2416:26
MOH
Molina Healthcare
The company states:… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Impinj reports Q1 adjusted EPS 21c, consensus 11c »
16:26
04/24/24
04/24
16:26
04/24/2416:26
PI
Impinj
Reports Q1 revenue… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Origin Bancorp reports Q1 adjusted EPS 73c, consensus 60c »
16:26
04/24/24
04/24
16:26
04/24/2416:26
OBK
Origin Bancorp
At March 31, 2024, and… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Molina Healthcare reports Q1 EPS $5.73, consensus $5.59 »
16:26
04/24/24
04/24
16:26
04/24/2416:26
MOH
Molina Healthcare
Reports Q1 revenue… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Landstar System reports Q1 EPS $1.32, consensus $1.28 »
16:25
04/24/24
04/24
16:25
04/24/2416:25
LSTR
Landstar System
Reports Q1 revenue… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Chemed backs FY24 adjusted EPS view $23.30-$23.70, consensus $23.52
16:25
04/24/24
04/24
16:25
04/24/2416:25
CHE
Chemed
|
Earnings
|
United Rentals raises FY24 revenue view to $14.95B-$15.45B, consensus $15.04B »
16:25
04/24/24
04/24
16:25
04/24/2416:25
URI
United Rentals
Previous view… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Chemed reports Q1 adjusted EPS $5.20, consensus $5.48 »
16:25
04/24/24
04/24
16:25
04/24/2416:25
CHE
Chemed
Reports Q1 revenue… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
United Rentals reports Q1 adjusted EPS $9.15, consensus $8.32 »
16:25
04/24/24
04/24
16:25
04/24/2416:25
URI
United Rentals
Reports Q1 revenue… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
General news
|
Treasury Market Summary: »
16:25
04/24/24
04/24
16:25
04/24/2416:25
$ECON
Economic Data
Treasury Market Summary:… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Plexus sees Q3 adjusted EPS $1.22-$1.37, consensus $1.09 »
16:24
04/24/24
04/24
16:24
04/24/2416:24
PLXS
Plexus
Sees revenue $960M-$1B,… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Wyndham Hotels raises 2024 adjusted EPS view to $4.18-$4.30 from $4.11-$4.23 »
16:24
04/24/24
04/24
16:24
04/24/2416:24
WH
Wyndham Hotels
Consensus for 2024 EPS is… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Third Coast Bancshares reports Q1 EPS 61c, consensus 49c »
16:24
04/24/24
04/24
16:24
04/24/2416:24
TCBX
Third Coast Bancshares
"Third Coast's… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |