2020-12-04 05:14:32 GSK GSK
Dynavax
12/04/20 12/0405:14 12/04/2005:14 | Clover announces data for COVID-19 S-Trimer vaccine candidatesClover Biopharmaceuticals announced clinical data from its Phase 1 trial demonstrating that its protein-based COVID-19 S-Trimer vaccine candidates in combination with adjuvants from either GlaxoSmithKline (GSK) or Dynavax (DVAX) induces strong immune responses, including neutralizing antibodies and cell-mediated immunity, as well as favorable safety and tolerability profiles in 150 adult and elderly participants. The Phase 1 trial was a randomized, observer-blind, placebo-controlled study to assess the safety, reactogenicity and immunogenicity of the adjuvanted COVID-19 S-Trimer vaccine candidates formulated with different antigen levels. No serious adverse events related to the vaccine candidates studied were reported. The majority of adverse events were mild and transient. S-Trimer adjuvanted with GSK's pandemic adjuvant system induced neutralizing antibody titers in 100% of participants at the selected 9 microgram S-Trimer dose in both adult and elderly groups, with geometric mean titers, or GMT, greater than 1:1,800. CpG-1018/alum-adjuvanted S-Trimer induced neutralizing antibodies in 100% of adult participants at the selected 30 microgram S-Trimer dose with GMT greater than 1:1,000, and seroconversion was observed in 88% in elderly. Strong Th1 cell-mediated immune responses were also observed for the vaccine candidates with either adjuvant. Preliminary results from stability studies have demonstrated that S-Trimer is stable at 2-8 degrees Celsius for at least six months and stable at room temperature and 40 degrees Celsius for at least one month, in line with the adjuvants tested. Thus, the ability of Clover's COVID-19 vaccine candidates to be stored in standard refrigeration temperatures makes them suitable for broad global distribution based on current results. Based on the Phase 1 results reported and the unprecedented need for COVID-19 vaccines, Clover and its partners said they are confident to enter late-stage clinical development for both adjuvanted vaccines. A global Phase 2/3 efficacy study of the S-Trimer vaccine candidate in combination with GSK's pandemic adjuvant system is expected to begin in December. Clover intends to initiate a separate pivotal clinical trial of the S-Trimer vaccine candidate in combination with Dynavax's advanced CpG 1018 adjuvant plus alum in the first half of 2021. GSK
Dynavax
|
|
---|
Hot Stocks
|
Smart for Life Inc trading halted, news pending
19:50
04/19/24
04/19
19:50
04/19/2419:50
SMFL
Smart for Life
|
Hot Stocks
|
Windtree Therapeutics Inc trading halted, news pending
19:50
04/19/24
04/19
19:50
04/19/2419:50
WINT
Windtree Therapeutics
|
Hot Stocks
|
Portland General Electric raises quarterly dividend 5.3% to 50c per share »
18:04
04/19/24
04/19
18:04
04/19/2418:04
POR
Portland General Electric
On April 19, the board of… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
NovaBay receives NYSE American notice of non-compliance »
18:01
04/19/24
04/19
18:01
04/19/2418:01
NBY
NovaBay
NovaBay Pharmaceuticals… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Oragenics announces NYSE American noncompliance notification »
17:53
04/19/24
04/19
17:53
04/19/2417:53
OGEN
Oragenics
Oragenics announced that… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Wrap Technologies receives noncompliance notification from Nasdaq »
17:30
04/19/24
04/19
17:30
04/19/2417:30
WRAP
Wrap Technologies
Wrap Technologies… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
HII awarded $120.3M Navy contract modification »
17:25
04/19/24
04/19
17:25
04/19/2417:25
HII
HII
HII was awarded a $120.3M… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Arista Networks COO Anshul Sadana to resign, effective May 21 »
17:19
04/19/24
04/19
17:19
04/19/2417:19
ANET
Arista Networks
In a regulatory filing,… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Syndicate
|
InnSuites Hospitality Trust files to sell 1M shares of common stock
17:16
04/19/24
04/19
17:16
04/19/2417:16
IHT
InnSuites Hospitality Trust
|
Syndicate
|
Inhibikase Therapeutics files to sell common stock, warrants, no amount given »
17:16
04/19/24
04/19
17:16
04/19/2417:16
IKT
Inhibikase Therapeutics
Maxim Group is acting as… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Aslan Pharmaceuticals receives Nasdaq notice »
17:13
04/19/24
04/19
17:13
04/19/2417:13
ASLN
Aslan Pharmaceuticals
Aslan Pharmaceuticals… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Syndicate
|
Zai Lab files automatic ordinary shares offering
17:13
04/19/24
04/19
17:13
04/19/2417:13
ZLAB
Zai Lab
|
Syndicate
|
Endra Life Sciences files to sell common stock, warrants, no amount given »
17:12
04/19/24
04/19
17:12
04/19/2417:12
NDRA
Endra Life Sciences
Craig-Hallum is sole… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Hepion Pharmaceuticals falls 42% after wind down of ASCEND-NASH trial »
17:08
04/19/24
04/19
17:08
04/19/2417:08
HEPA
Hepion Pharmaceuticals
In after-hours trading,… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
NLS Pharmaceutics receives staff delisting determination letter from Nasdaq »
17:05
04/19/24
04/19
17:05
04/19/2417:05
NLSP
NLS Pharmaceutics
NLS Pharmaceutics… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Conference/Events
|
Steelcase management to meet with Benchmark »
17:04
04/19/24
04/19
17:04
04/19/2417:04
SCS
Steelcase
Group breakfast at 7:45am… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Syndicate
|
AIM ImmunoTech files to sell 9.98M shares of common stock for holders
17:03
04/19/24
04/19
17:03
04/19/2417:03
AIM
AIM ImmunoTech
|
Hot Stocks
|
Lion Group receives noncompliance notification from Nasdaq »
17:03
04/19/24
04/19
17:03
04/19/2417:03
LGHL
Lion Group
Lion Group announced that… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Syndicate
|
RenovoRx files to sell 6.13M shares of common stock for holders
17:03
04/19/24
04/19
17:03
04/19/2417:03
RNXT
RenovoRx
|
Syndicate
|
Yoshiharu files to sell 237,885 shares of Class A common stock for holders
17:02
04/19/24
04/19
17:02
04/19/2417:02
YOSH
Yoshiharu
|
Hot Stocks
|
Hepion Pharmaceuticals trading resumes
17:00
04/19/24
04/19
17:00
04/19/2417:00
HEPA
Hepion Pharmaceuticals
|
General news
|
Treasury Market Summary: »
16:55
04/19/24
04/19
16:55
04/19/2416:55
$ECON
Economic Data
Treasury Market Summary:… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Conference/Events
|
Oppenheimer healthcare analysts hold an analyst/industry conference callssssssss »
16:51
04/19/24
04/19
16:51
04/19/2416:51
Healthcare Analysts,… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Asbury Automotive chief legal officer George Villasana to retire »
16:40
04/19/24
04/19
16:40
04/19/2416:40
ABG
Asbury Automotive
Asbury Automotive… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Conference/Events
|
Editas Medicine management to meet with Oppenheimer »
16:36
04/19/24
04/19
16:36
04/19/2416:36
EDIT
Editas Medicine
Meeting to be held on… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |