2021-02-10 18:49:40 MESO Mesoblast
02/10/21 02/1018:49 02/10/2118:49 | Mesoblast's chronic back pain therapy shows efficacy and opioid use reductionMesoblast announced results from the Phase 3 randomized controlled trial of its allogeneic mesenchymal precursor cell - MPC - therapy rexlemestrocel-L in 404 enrolled patients with chronic low back pain due to degenerative disc disease refractory to conventional treatments. Results indicate that a single injection of rexlemestrocel-L may provide a safe, durable, and effective opioid-sparing therapy for patients with chronic inflammatory back pain due to degenerative disc disease, and that greatest benefits are seen when administered earlier in the disease process. A single injection of MPC + Hyaluronic Acid (HA) carrier resulted in significant and durable reductions in CLBP through 24 months across the entire evaluable study population; significantly greater pain reduction in the patient subset of opioid users; increased composite outcomes of reduction in pain together with improvement in function in those with CLBP of shorter duration than 68 months; however, the composite outcomes of pain and function did not reach statistical significance across the entire study. No safety concerns over the 24-month period of follow-up in the entire study population. Mesoblast will meet with the FDA to discuss the results from this trial together with the earlier trial of MPC + HA, and potential approval pathways for rexlemestrocel-L + HA as treatment for durable reduction in CLBP due to DDD with opioid sparing activity. |
---|
Recommendations
|
Alcoa price target raised by $5 at UBS, here's why »
22:00
04/18/24
04/18
22:00
04/18/2422:00
AA
Alcoa
UBS raised the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
Dell Technologies price target raised by $28 at UBS, here's why »
21:58
04/18/24
04/18
21:58
04/18/2421:58
DELL
Dell Technologies
UBS raised the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
PPG price target lowered by $6 at UBS, here's why »
21:55
04/18/24
04/18
21:55
04/18/2421:55
PPG
PPG
UBS analyst Joshua… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
Netflix's reduced disclosures may disappoint the Street, says Citi »
21:52
04/18/24
04/18
21:52
04/18/2421:52
NFLX
Netflix
Citi keeps a Neutral… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
United Airlines price target raised by $13 at Bernstein, here's why »
21:48
04/18/24
04/18
21:48
04/18/2421:48
UAL
United Airlines
Bernstein raised the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
Abbott Q1 strong but still in penalty box on litigation overhang, says Bernstein »
21:44
04/18/24
04/18
21:44
04/18/2421:44
ABT
Abbott
Bernstein analyst Lee… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Cumulus Media sees Q1 revenue $199M-$201M, two estimates $200.8M »
21:40
04/18/24
04/18
21:40
04/18/2421:40
CMLS
Cumulus Media
Sees Q1 adjusted EBITDA… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
DLocal transferred with Neutral rating at Citi »
21:24
04/18/24
04/18
21:24
04/18/2421:24
DLO
DLocal
Citi kept a Neutral… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Recommendations
|
Citizens Financial price target raised by $4 at Citi, here's why »
21:22
04/18/24
04/18
21:22
04/18/2421:22
CFG
Citizens Financial
Citi raised the… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Upgrade
|
Bradesco BBI gets more bullish on Credicorp, upgrades shares »
21:20
04/18/24
04/18
21:20
04/18/2421:20
BAP
Credicorp
Bradesco BBI analyst… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Earnings
|
Notable companies reporting before tomorrow’s open »
20:25
04/18/24
04/18
20:25
04/18/2420:25
PG
Procter & Gamble
American Express
Notable companies… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Cathie Wood's ARK Investment buys 255.3K shares of PacBio today
20:14
04/18/24
04/18
20:14
04/18/2420:14
PACB
PacBio
|
Hot Stocks
|
Cathie Wood's ARK Investment buys 116.4K shares of 10x Genomics today
20:13
04/18/24
04/18
20:13
04/18/2420:13
TXG
10x Genomics
|
Hot Stocks
|
Cathie Wood's ARK Investment buys 88.3K shares of Tesla today
20:12
04/18/24
04/18
20:12
04/18/2420:12
TSLA
Tesla
|
Hot Stocks
|
SK hynix, TSMC to partner on next-generation HBM technology »
20:02
04/18/24
04/18
20:02
04/18/2420:02
TSM
TSMC
SK Hynix
SK hynix (HXSCL)… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Golden Sun Health Technology Group Ltd trading halted, news pending
19:50
04/18/24
04/18
19:50
04/18/2419:50
GSUN
Golden Sun Education Group
|
Downgrade
|
Ulta Beauty just downgraded at Jefferies, here's why »
19:37
04/18/24
04/18
19:37
04/18/2419:37
ULTA
Ulta Beauty
Jefferies downgraded Ulta… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Periodicals
|
Amazon renews 'Fallout' series for second season, Variety reports »
19:08
04/18/24
04/18
19:08
04/18/2419:08
AMZN
Amazon.com
Microsoft
Amazon (AMZN) has renewed… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
FDA approves subcutaneous administration of Takeda's ENTYVI in Crohn's disease »
19:03
04/18/24
04/18
19:03
04/18/2419:03
TAK
Takeda
Takeda "announced… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Initiation
|
Loop Capital starts DoorDash at Buy, sees premium justified by higher growth »
19:00
04/18/24
04/18
19:00
04/18/2419:00
DASH
DoorDash
As previously reported,… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Initiation
|
Loop Capital starts Instacart at Buy on growing market share »
18:56
04/18/24
04/18
18:56
04/18/2418:56
CART
Instacart
DoorDash
Uber
As previously reported,… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
Paramount up 12% after NY Times report of joint bid from Sony, Apollo Global »
18:53
04/18/24
04/18
18:53
04/18/2418:53
PARA
Paramount
Sony
Apollo Global
In after-hours trades,… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
NeoGames, Aristocrat Leisure receive regulatory approval on proposed acquisition »
18:35
04/18/24
04/18
18:35
04/18/2418:35
NGMS
NeoGames
NeoGames S.A.… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Periodicals
|
Sony, Apollo in talks over joint bid for Paramount, NY Times reports »
18:18
04/18/24
04/18
18:18
04/18/2418:18
SONY
Sony
Apollo Global
Paramount
Paramount
Sony Pictures (SONY) and… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |
Hot Stocks
|
MSP Recovery, Inc. reaches comprehensive settlement with 10 insurers »
18:12
04/18/24
04/18
18:12
04/18/2418:12
LIFW
MSP Recovery, Inc.
MSP Recovery, Inc. d/b/a… Available to The Fly Members Only Breaking content available to members only. Sign up or login for access. Create FREE Account |